Yuribecca (Yuri X Rebecca) and Adray (Adrienne X Ray) = two of my favorite OC X OC OTPs.
My long list of favorite game franchises:
Hudson Soft - Bloody Roar, Bomberman
Square Enix - Final Fantasy (except FFXV. said game's fanbase annoys me), Kingdom Hearts
Arc System Works - BlazBlue, Persona 4 Arena duology, Guilty Gear
Capcom - Street Fighter, Resident Evil, Devil May Cry, Ōkami, Sengoku BASARA, crossover games with Marvel
KOEI TECMO (and Gust) - Dynasty Warriors, Samurai Warriors, Warriors Orochi, Geten no Hana, Dead or Alive, Mana Khemia
Namco Bandai - Tekken, Tales series, Soul series
Persona series (except P1)
Too many I can't put them all in.